Investigating the Potential Mechanism of Microneedling in Alopecia Areata Mice Based on 16S rRNA Sequencing and Metabolomics

    August 2025 in “ Frontiers in Microbiology ”
    Yue Zhang, Lu Li, Lei Cao, Rushan Xia
    Studysummary This study found that microneedling treatment improved hair regeneration in an animal model of alopecia areata and positively influenced the gut microbiome by restoring microbial diversity and altering short-chain fatty acid levels.
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    Research cited in this study 10

    1. Growth Factors and Microneedling in Alopecia Areata: A Narrative Review Skin appendage disorders · 2024
    2. Alopecia Areata and Risk of Atopic and Autoimmune Conditions: Population-Based Cohort Study Clinical and Experimental Dermatology · 2022
    3. The Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss Life · 2022
    4. How Our Microbiome Influences the Pathogenesis of Alopecia Areata Genes · 2022
    5. Gut Microbiota in Alopecia Areata Advances in Dermatology and Allergology · 2022
    6. The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications Cells · 2021
    7. Microneedling and Its Use in Hair Loss Disorders: A Systematic Review Dermatology and therapy · 2021
    8. Common Causes of Hair Loss: Clinical Manifestations, Trichoscopy, and Therapy Journal of the European Academy of Dermatology and Venereology · 2020
    9. Alopecia Areata and the Gut: The Link Opens Up for Novel Therapeutic Interventions Expert Opinion on Therapeutic Targets · 2018
    10. Microneedling for the Treatment of Hair Loss Journal of The European Academy of Dermatology and Venereology · 2017

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