Effect of Varied Hair Protein Fractions on the Gel Properties of Keratin/Chitosan Hydrogels for Use in Tissue Engineering

November 2020 in “ Colloids and surfaces. B, Biointerfaces ”

Tingyu Lu, Wen-Chuan Huang, Yi Chen, Nareshkumar Baskaran, Jihong Yu, Yang Wei

keratin chitosan keratin-associated proteins keratin intermediate filaments hydrogels tissue engineering KAPs KIFs

TLDR Different hair protein amounts change the strength of keratin/chitosan gels, useful for making predictable tissue engineering materials.

The study investigated the impact of different hair protein fractions on the properties of keratin/chitosan hydrogels, which are used in tissue engineering. Specifically, it looked at how varying the ratios of keratin-associated proteins (KAPs) and keratin intermediate filaments (KIFs) within the hydrogel affected its mechanical strength. The study found that by adjusting the KAPs/KIFs ratios, the compressive and tensile modulus of the hydrogel could be controlled, leading to more consistent gel properties. This suggests a method for preparing keratin/chitosan hydrogels with predictable characteristics, which is beneficial for their application in tissue engineering.

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