Hair Follicle Culture

January 2012 in “ Methods in pharmacology and toxicology ”

Michael P. Philpott

hair follicle culture hair growth regulatory factors drug responses signal transduction pathways siRNA hair biology regulation

TLDR Hair follicle culture helps study hair growth but has limitations in modeling the full hair cycle.

Hair follicle organ culture allowed the maintenance of individual hair follicles from various species in culture, enabling the study of hair growth regulatory factors, drug responses, and signal transduction pathways. Despite its usefulness, the model had limitations, such as the inability to model the entire hair cycle in vitro and difficulty in maintaining follicles beyond 10 days. However, it showed promise for use with siRNA to enhance understanding of hair biology regulation.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

research Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth

105 citations, May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

Activating TRPV3 stops human hair growth.

research Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture

132 citations, September 2009 in “Experimental Dermatology”

A reliable system was developed to distinguish hair growth stages, aiding in identifying hair growth promoters or inhibitors.

research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

53 citations, January 2009 in “Journal of Investigative Dermatology”

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

research Temporary Hair Removal by Low Fluence Photoepilation: Histological Study on Biopsies and Cultured Human Hair Follicles

134 citations, September 2008 in “Lasers in surgery and medicine”

Low fluence photoepilation temporarily removes hair by targeting the hair follicle's pigmented area without severe damage.

research Dissecting the Impact of Chemotherapy on the Human Hair Follicle

99 citations, September 2007 in “The American journal of pathology”

Chemotherapy damages hair follicles, causing hair loss and other cellular changes.

Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

128 citations, March 2006 in “American Journal of Pathology”

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations, June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

research Cyclical Changes in Rat Vibrissa Follicles Maintained In Vitro

34 citations, December 2000 in “The journal of investigative dermatology/Journal of investigative dermatology”

Rat vibrissa follicles are useful for studying hair growth cycles, especially the transition from pro-anagen to anagen.

research Serum-Free Culture of Wool Follicles: Effects of Nutrients, Growth Factors, and Hormones

11 citations, October 1997 in “British Journal of Dermatology”

Wool follicles grew fibres for 8-10 days in a serum-free culture, influenced by calcium, glucose, amino acids, and insulin.

research Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition

42 citations, February 1996 in “Journal of Investigative Dermatology”

research Hair Growth In Vitro From Histocultured Skin

25 citations, August 1992 in “In vitro cellular & developmental biology”

The new system can grow hair in the lab and test hair growth treatments.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

121 citations, March 1989 in “Journal of Investigative Dermatology”

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

Related Community Posts Join

6 / 1000+ results

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Why I deleted my YouTube channel Part I

in Update 118 upvotes 3 years ago

A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 5 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community Epibiotech will now offer off-the-shelf allogeneic hair multiplication treatment in South Korea

in Research/Science 78 upvotes 2 years ago

Epibiotech will offer off-the-shelf allogeneic hair multiplication treatment in South Korea, using dermal papilla cells from donors to grow hair in balding areas. This method is cheaper and less invasive than traditional hair transplants.

community Wait, so retinol actually helps with hair growth? I heard it was the other way around a while ago and just accepted it..

in Treatment 6 upvotes 5 years ago

Retinol can help with hair growth, contrary to previous beliefs. Treatments discussed include Minoxidil, finasteride, and RU58841.

Related Research

2 / 2 results

research Blockade of S100A3 Activity Inhibits Murine Hair Growth

1 citations, January 2015 in “Genetics and Molecular Research”

Stopping S100A3 activity slows down hair growth in mice.

Human Hair Growth Ex Vivo Is Correlated With In Vivo Hair Growth: Selective Categorization of Hair Follicles for More Reliable Hair Follicle Organ Culture

research Human Hair Growth Ex Vivo Is Correlated With In Vivo Hair Growth: Selective Categorization of Hair Follicles for More Reliable Hair Follicle Organ Culture

27 citations, November 2005 in “Archives of Dermatological Research”

Choosing hair follicles at the same growth stage leads to more consistent hair growth experiments.