Hair Follicle Culture

January 2012 in “ Methods in pharmacology and toxicology ”

Michael P. Philpott

hair follicle culture hair growth regulatory factors drug responses signal transduction pathways siRNA hair biology regulation

TLDR Hair follicle culture helps study hair growth but has limitations in modeling the full hair cycle.

Hair follicle organ culture allowed the maintenance of individual hair follicles from various species in culture, enabling the study of hair growth regulatory factors, drug responses, and signal transduction pathways. Despite its usefulness, the model had limitations, such as the inability to model the entire hair cycle in vitro and difficulty in maintaining follicles beyond 10 days. However, it showed promise for use with siRNA to enhance understanding of hair biology regulation.

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Research cited in this study

12 / 12 results

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research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

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Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations, June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

research Cyclical Changes in Rat Vibrissa Follicles Maintained In Vitro

34 citations, December 2000 in “The journal of investigative dermatology/Journal of investigative dermatology”

Rat vibrissa follicles are useful for studying hair growth cycles, especially the transition from pro-anagen to anagen.

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