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research Exposure to gamma-rays at the telogen phase of the hair cycle inhibits hair follicle regeneration at the anagen phase in mice

November 2013 in “Institutional Repositories DataBase (IRDB)”

In this study, γ-ray exposure in mice decreased hair follicle density and pigmentation, suggesting damage to stem cells affecting hair follicle regeneration.

research Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling

158 citations , February 2012 in “Journal of Investigative Dermatology”

FGF18 helps keep hair in its resting phase, affecting hair growth cycles.

research Faculty Opinions recommendation of Hair cycle resting phase is regulated by cyclic epithelial FGF18 signaling.

August 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

This study found that FGF18 is crucial for regulating hair follicle rest and growth phases, as its absence in mice leads to a shorter resting phase and rapid hair cycling.

research 1103 Derinat extends hair cycle at anagen phase by decreasing the level of TRPCs-mediated intracellular ROS accumulation in skin

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that Derinat treatment in mice maintained the hair cycle in the anagen phase and reduced TRPCs-mediated intracellular ROS accumulation, potentially improving hair growth by altering the skin microenvironment.

research De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle

41 citations , June 2010 in “Journal of Investigative Dermatology”

This study suggests that new cells are incorporated into the dermal papilla during the early anagen phase of the hair cycle, which may influence hair growth consistency and follicle size changes.

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Learn

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learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
When will I see new hair growth after a hair transplant? New hair growth usually starts 2-4 months after a hair transplant.

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

learn Adenosine

nucleoside used for hair regrowth stimulant properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Latanoprost

glaucoma medication with hair follicle stimulant effects

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

learn Cyproterone

How long does it take for cyproterone to work on hair loss? There is no reliable published figure for how fast cyproterone works on hair loss: the hair cycle means nothing shows for months, the one randomised trial assessed women at twelve months, and community reports range from about six months to two years — with some people seeing no change at all.

learn horsetail extract

How long should you use horsetail extract before noticing stronger or thicker hair? No published trial has tested horsetail extract for hair thinning, so no evidence-based timeline exists; the hair cycle means any supplement needs at least three months, and more realistically five to six, before a change could be visible at all.

learn Rapamycin

Is rapamycin safe for long-term use on the scalp, or should it be used in cycles? There is no published human trial of topical rapamycin on the scalp, so nobody knows whether long-term use is safe; the idea of cycling it comes from community practice and theory, not from any study or guideline, and rapamycin for hair loss is an off-label use of a prescription immunosuppressant.

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Community Join

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community if hair follicle miniaturization happens slowly and gradually over a few hair cycles then wouldn't that mean that to regain maximum or top thickness from treatment you would at least need 5-10 years?

in Research/Science 53 upvotes 10 months ago

Hair regrowth from treatments like finasteride, dutasteride, and minoxidil can take several years, with most visible results appearing within 1-2 years and potential improvements continuing up to 10 years. Consistency and patience are crucial for achieving maximum hair thickness, as hair miniaturization and regrowth are gradual processes.

community PP405 Hair Loss Drug: Phase 1 Human Results & Biopsy Insights

213 upvotes 1 year ago

PP405 is a potential hair loss treatment undergoing trials, with discussions on its effectiveness and comparison to existing treatments like finasteride and minoxidil. There is skepticism about its status as a cure, with hopes for future advancements in genetic treatments like CRISPR.

community Circadian rhythm disruption and its potential impact on hair growth cycles

in Technology 7 upvotes 4 months ago

Poor sleep quality may affect hair growth cycles by disrupting the body's natural clock and stress hormones. The focus should be on improving sleep to support overall health, including hair growth, rather than relying solely on treatments like Minoxidil, finasteride, or RU58841.

community Hair thinning on dutasteride vs fin? No shed phase

in Finasteride/Dutasteride 18 upvotes 2 years ago

A user switched from finasteride to dutasteride to combat hair thinning but noticed overall thinner hair without shedding. Another user suggested that hair can't thin without shedding and recommended adding finasteride pills for peace of mind.

community Clascoterone 5% Delivers Strong Phase 3 Hair-Growth Results

371 upvotes 8 months ago

Clascoterone 5% solution shows strong potential for hair growth, offering a new treatment for alopecia with minimal side effects. It blocks androgen receptors locally and may be available by late 2026 or early 2027.

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Clinics

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