Effects of Lifelong Testosterone Exposure on Health and Disease Using Mendelian Randomization
October 2020
in “
eLife
”
testosterone Mendelian randomization type 2 diabetes prostate cancer polycystic ovary syndrome autoimmune diseases alopecia bone mineral density body fat androgenic alopecia spinal stenosis hypertension calculated free testosterone hematocrit percentage heel bone mineral density body fat-free percentage PCOS hair loss bone density male pattern baldness high blood pressure CFT hematocrit heel bone density lean body mass
Studysummary This study using Mendelian randomization in UK Biobank data suggests that lifelong increased free testosterone may have mixed effects, including increased bone density and prostate cancer risk, warranting well-powered trials to address uncertainties.
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