Sex-Related Differences in the Pharmacological Response in SARS-CoV-2 Infection, Dyslipidemia, and Diabetes Mellitus: A Narrative Review

    June 2023 in “ Pharmaceuticals ”
    Adelina Lombrea, Mirabela Romanescu, Narcisa Jianu … Valentina Buda
    Studysummary This review reports that sex-related differences in pharmacological response have been observed in SARS-CoV-2 infection, dyslipidemia, and diabetes mellitus, with implications for treatment strategies; for example, men may respond better to genomic vaccines for SARS-CoV-2, while women may benefit more from certain antiviral medications.
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    Research cited in this study 4

    1. GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects Frontiers in Endocrinology · 2021
    2. Anti-Androgens May Protect Against Severe COVID-19 Outcomes: Results From a Prospective Cohort Study of 77 Hospitalized Men Journal of The European Academy of Dermatology and Venereology · 2021
    3. Sex Differences in COVID-19: The Role of Androgens in Disease Severity and Progression Endocrine · 2020
    4. 5-Alpha-Reductase Inhibitors Are Associated With Reduced Frequency of COVID-19 Symptoms in Males With Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2020