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research Effects of Lifelong Testosterone Exposure on Health and Disease Using Mendelian Randomization

29 citations , October 2020 in “eLife”

Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.

research Decision Letter: Effects of Lifelong Testosterone Exposure on Health and Disease Using Mendelian Randomization

July 2020

Increased free testosterone can lead to stronger bones and less body fat but also higher risks of prostate cancer, hair loss, spine issues, and high blood pressure.

research Buschke-Ollendorff Syndrome: Clinical Features and Genetic Insights

1 citations , April 2016 in “British Journal of Dermatology”

Buschke-Ollendorff syndrome is a rare genetic disorder causing skin and bone changes, with some cases also showing ADHD or developmental delays.

research Author Response: Effects of Lifelong Testosterone Exposure on Health and Disease Using Mendelian Randomization

2 citations , September 2020

Long-term high testosterone levels can improve bone density and reduce body fat but may increase the risk of prostate cancer and high blood pressure.

WISP-1 Induced by Mechanical Stress Contributes to Fibrosis and Hypertrophy of the Ligamentum Flavum Through Hedgehog-Gli1 Signaling

research WISP-1 Induced by Mechanical Stress Contributes to Fibrosis and Hypertrophy of the Ligamentum Flavum Through Hedgehog-Gli1 Signaling

36 citations , June 2021 in “Experimental & Molecular Medicine”

Targeting Hedgehog signaling may help treat ligamentum flavum fibrosis.

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community No motivation to workout because I’ll be bald no matter what

in Chat 78 upvotes 1 year ago

The conversation is about hair loss affecting motivation to work out. The original poster is using dutasteride and minoxidil and is considering a hair transplant.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 84 upvotes 1 year ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 23 upvotes 4 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community 40 year old, 1 year on fin/min

in Progress Pictures 399 upvotes 1 month ago

A 40-year-old user shared their experience using finasteride and minoxidil for hair regrowth over a year, noting initial sexual side effects that improved after reducing the finasteride dosage. They also experienced scalp irritation from Rogaine, leading to reduced usage, and expressed satisfaction with the hair regrowth despite ongoing challenges.

community Just over 4 months in. Am I seeing things?

in Is this regrowth? 37 upvotes 2 years ago

The user reports potential hair regrowth after using finasteride nightly, minoxidil twice daily, occasional microneedling, and vitamin supplements, and is considering RU58841 in the future. Replies suggest they are seeing improvement.

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