Depletion of Gsdma1/2/3 Alleviates PMA-Induced Epidermal Hyperplasia by Inhibiting the EGFR–Stat3/Akt Pathway

The study explores the role of Gsdma1/2/3 genes in PMA-induced epidermal hyperplasia and inflammation, finding that their depletion in knockout mice alleviates these conditions by inhibiting the EGFR–Stat3/Akt pathway. This suggests that Gsdma1/2/3 genes are crucial for keratinocyte proliferation and that targeting these genes could be a potential therapeutic strategy for skin disorders characterized by epidermal hyperplasia. The research highlights the importance of the EGFR–Stat3/Akt pathway in regulating epidermal cell proliferation and suggests that Gsdma1/2/3 may act as stress-associated activators in response to external stimuli or internal disease changes.