Inducible Expression of Gasdermin A3 in the Epidermis Causes Epidermal Hyperplasia and Skin Inflammation

The study demonstrated that inducible expression of gasdermin A3 (Gsdma3) in the epidermis of a transgenic mouse model caused epidermal hyperplasia, skin inflammation, and hair cycle defects, indicating gain-of-function mutations. Gsdma3 expression led to spontaneous keratinocyte necrosis, linked to mitochondrial oxidative stress and an inflammatory response. These findings suggested that the Gsdma3-inducible mouse line could be useful for testing treatments for irritant contact dermatitis and immune-mediated hair loss.