Inducible Expression of Gasdermin A3 in the Epidermis Causes Epidermal Hyperplasia and Skin Inflammation

The study investigated the effects of inducible expression of gasdermin A3 (Gsdma3) in the epidermis using a doxycycline-inducible transgenic mouse model. The overexpression of Gsdma3 led to epidermal hyperplasia, skin inflammation, and hair cycle defects, suggesting that Gsdma3 mutations were gain-of-function. Histological analysis showed increased cell proliferation and inflammatory cell infiltration in the skin. The study also found that Gsdma3 expression induced mitochondrial oxidative stress and keratinocyte necrosis, contributing to inflammation. These findings indicated that Gsdma3 played a role in skin inflammation and hair loss, and the mouse model could be useful for testing treatments for related conditions.