N-Terminal Functional Domain of Gasdermin A3 Regulates Mitochondrial Homeostasis via Mitochondrial Targeting

    June 2015 in “ Journal of biomedical science ”
    Pei‐Hsuan Lin, Hsien‐Yi Lin, Cheng-Chin Kuo, Liang‐Tung Yang
    Studysummary This study demonstrated that dominant mutations in mouse gasdermin A3 disrupt mitochondrial oxidative stress regulation, suggesting a gain-of-function effect on epidermal differentiation.
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    Research cited in this study 7

    1. Cell Death by Cornification Biochimica et biophysica acta. Molecular cell research · 2013
    2. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013
    3. Upregulation of Interfollicular Epidermal and Hair Infundibulum β-Catenin Expression in Gsdma3 Mutant Mice Acta histochemica · 2012
    4. Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation American Journal Of Pathology · 2011
    5. Gsdma3 Is Required for Hair Follicle Differentiation in Mice Biochemical and biophysical research communications · 2010
    6. Cell Death in the Skin: Mechanisms and Implications Apoptosis · 2009
    7. Defolliculated (Dfl): A Dominant Mouse Mutation Leading to Poor Sebaceous Gland Differentiation and Total Elimination of Pelage Follicles Journal of Investigative Dermatology · 2002