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GlossaryHair Follicle Bulge (bulge)

specific region housing stem cells for hair growth

The hair follicle bulge is a specific region located in the outer root sheath of the hair follicle. It serves as a reservoir for stem cells that are crucial for hair growth and regeneration, as well as for repairing the skin after injury. This area is essential for the cyclical nature of hair growth and plays a significant role in conditions like alopecia.

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community M32, almost 3 moths, fin oral 1,25g/daily + min 2xday + keto 2% shapoo 1/week microneedling once a week

in Progress Pictures 31 upvotes 1 year ago

A 32-year-old man has been treating his hair loss with daily oral finasteride (1.25g), twice-daily topical minoxidil, weekly ketoconazole 2% shampoo, and weekly microneedling for almost three months, with no side effects from finasteride. He started with a Hamilton Norwood scale rating of 5 and has seen improvement without experiencing pain by using a 0.8mm needle length for microneedling.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 2 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Hair theory Scar tissue and Verteporfin

in Chat 25 upvotes 5 months ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

community Micro needling 25 days progress. I’ve been on fin and min for 6 months but micro needling has done SO much more to actually restore my hairline

in Progress Pictures 569 upvotes 8 months ago

A user shared a 25-day progress picture showing significant hairline restoration attributed to microneedling, in addition to using minoxidil and finasteride for 6 months. Other users discussed needle length, frequency, and whether the effects of microneedling are permanent.

community Best Microneedle Lengths To Stimulate Stem Cells

in Microneedling 18 upvotes 1 year ago

Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

community RU58841 alone vs. with Fin / Dut

in Finasteride/Dutasteride 11 upvotes 1 year ago

RU58841 combined with finasteride or dutasteride is more effective than RU58841 alone for hair loss. Users suggest combining these with minoxidil and microneedling for better results.

community Dutasteride Mesotherapy Works – Just 1 month results

in Progress Pictures 109 upvotes 2 years ago

The effectiveness of using dutasteride mesotherapy as a hair loss treatment, with other protocols such as microneedling, vitamin D and B12, zinc, and biotin. The user's results were positive after 4-6 months without any serious side effects.

community Redensyl Megathread !!!!

44 upvotes 4 years ago

Redensyl, which is a topical alternative to Minoxidil for hair loss. It may have advantages such as not making the hair greasy and lasting longer after discontinuing use than minoxidil. There are some positive reports from users, but also some negative ones, so it's unclear how effective this treatment will be in comparison to Minoxidil and other treatments like Finasteride or RU58841.

community 6 month hairline results (dutasteride and microneedling)

in Progress Pictures 805 upvotes 4 years ago

A user's 6 month hairline results from using dutasteride and microneedling, which resulted in successful regrowth of their thinning temples. Other users commented with similar experiences that were also achieved through the use of finasteride, dutasteride and minoxidil.

community My microneedling journey (no min, fin, etc)

in Microneedling 194 upvotes 1 month ago

The user experienced positive hair growth results using microneedling with rosemary and mint oil, without Minoxidil, Finasteride, or RU58841. They switched from a dermaroller to a microneedling pen and targeted different scalp areas weekly.

community No motivation to workout because I’ll be bald no matter what

in Chat 78 upvotes 1 month ago

The conversation is about hair loss affecting motivation to work out. The original poster is using dutasteride and minoxidil and is considering a hair transplant.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 1 month ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community microneedle, any long term users damage?

in Microneedling 35 upvotes 6 months ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community Neck tension, and hair loss, I am 100 percent sure that there is a connection

in Treatment 19 upvotes 6 months ago

The user believes neck tension and poor posture contribute to hair loss, noticing improvements with yoga and muscle relaxation. Replies suggest androgenic alopecia as the cause and recommend exercises.

community A Nuanced Look at Microdosing Topical Finasteride

in Finasteride/Dutasteride 85 upvotes 11 months ago

The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Starting the microneedling only journey. M35 with diffuse thinning. Derminator 2, keto, vitamins and castor oil.

in Microneedling 15 upvotes 2 years ago

A user is starting a microneedling regimen for hair loss, using Derminator 2, ketoconazole shampoo, castor oil, and multivitamins. They plan to provide monthly updates on their progress.

community What are your thoughts on Redensyl? 85% success rate?!

in Treatment 6 upvotes 2 years ago

Hair loss discussion mentions Redensyl with 85% success rate and visible regrowth. Users skeptical, prefer Minoxidil, Finasteride, and RU58841.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Clearing the air on how non-surgical treatments really work

18 upvotes 5 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 5 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community Starting 2022 off by biting the bullet and starting fin

in Finasteride/Dutasteride 6 upvotes 2 years ago

The user started finasteride at 0.25 mg daily, using Nizoral 1-2 times per week, and microneedling once a week for hair loss. They hope to see positive results and share progress in a few months.

community Hair Loss Treatments On a Budget, A Scientific Approach (Topical Finasteride, Minoxidil, Tretinoin, Castor + Peppermint Oil and more)

in Finasteride 8 upvotes 8 years ago

The conversation discusses affordable hair loss treatments, including topical finasteride, minoxidil, tretinoin, and natural remedies like castor and peppermint oil. Specific treatments for hair loss are the focus.

community Alotendin=Loniten?! Bulgaria Oral Minoxidil

in Minoxidil 2 upvotes 1 month ago

The conversation discusses hair loss treatments, specifically oral Minoxidil, also known as Loniten or Alotendin in Bulgaria. It also mentions considering IndiaMart for purchasing options.

community [24M] - been taking oral Finasteride 1mg/day for 6 months + been using nanoxidil for 10 months, recently switched to Oral minoxidil 2.5mg daily - Literally no progress. What should I do? I dont have problem with budget, but I dont want to do something useless. Should I undergo PRP + exosomes? Ideas?

in Treatment 3 upvotes 2 months ago

A 24-year-old male has been using oral Finasteride 1mg/day for 6 months and nanoxidil for 10 months, recently switching to oral Minoxidil 2.5mg daily, with no progress. Suggestions include getting a scalp biopsy, consulting a dermatologist, and possibly trying higher doses of oral Minoxidil or switching to dutasteride.

community How to mix powder form fluridil in topical solution?

in Research/Science 1 upvotes 2 months ago

OP wants to buy fluridil from China and needs advice on mixing it in a topical solution due to budget constraints. They cannot afford Eucapil.

community Best Hair Transplant Surgeons for Hairline Work and Density Outside of the US?

in Transplants 4 upvotes 1 year ago

A user is seeking recommendations for top hair transplant surgeons outside the US, focusing on hairline work and density, with a budget of $3,000 to $8,000. They prefer locations closer than Turkey due to travel constraints.

community 6 Month Update: Finasteride 1mg + Minoxidil + Nizoral

in Progress Pictures 314 upvotes 1 year ago

With some minox This conversation is about a user, Jmilei, who has been using the "big three" hair loss treatments (Finasteride, Minoxidil, and Ketoconazole) for five years. After taking a two year break from treatment, they have recently restarted their regime and noticed results in the fourth month.

community "Things are now in motion that cannot be undone." First Fin tablet taken today.

in Finasteride/Dutasteride 102 upvotes 3 months ago

A user started taking finasteride due to increased hair shedding and sought advice on coping with the anxiety of starting the treatment. Responses included personal experiences with finasteride, minoxidil, and tips for integrating the medication into daily routines.