TLDR UV exposure reduces Lgr6+ stem cells in mouse skin and they don't significantly contribute to skin cancer development.
The study investigated the role of Lgr6+ stem cells in mouse epidermis during UV and chemical carcinogenesis. Researchers found that while Lgr6+ stem cells and their progeny were active in the interfollicular epidermis (IFE) and hair follicles under carcinogenic conditions, they were notably absent in the resulting skin tumors. This suggested that Lgr6+ stem cells did not contribute to tumor formation, highlighting the importance of quiescent stem cells in skin carcinogenesis. Detailed molecular analyses, including methylation-specific melting curve analysis and quantitative real-time PCR, supported these findings.
8 citations
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July 2016 in “Oncotarget” Lgr5+ stem cells do not cause skin tumors.
141 citations
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May 2007 in “Cancer Research” The study investigated the role of the cell surface marker CD34 in tumor development using CD34 knockout (KO) mice. CD34 is known to mark hair follicle bulge cells, which have stem cell properties. The research tested the hypothesis that CD34 is involved in skin tumor development, as hair follicle stem cells are major targets of carcinogens. CD34KO mice did not develop papillomas when initiated with 200 nmol of DMBA and promoted with TPA for 20 weeks. However, increasing the DMBA dose to 400 nmol led to tumor development in CD34KO mice, but with increased latency and lower tumor yield compared to wild-type mice. Despite metabolic activation of DMBA into carcinogenic forms, CD34KO mice showed sustained epidermal hyperplasia but their hair follicles remained in the telogen phase. The study concluded that CD34 is essential for TPA-induced activation of hair follicle stem cells and subsequent tumor formation in mice.
1 citations
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January 2016 in “Elsevier eBooks” The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.
1 citations
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January 2021 CD4+ skin cells may be precursors to basal cell carcinoma.
85 citations
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July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
10 citations
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January 2013 in “Journal of skin cancer” PKC ε increases hair follicle stem cell turnover and may raise skin cancer risk.
41 citations
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December 2018 in “Experimental Dermatology” Understanding how melanocyte stem cells work could lead to new treatments for hair graying and skin pigmentation disorders.
