Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice Following Topical Application of Fluocinolone Acetonide

    November 2007 in “ Journal of Investigative Dermatology ”
    Rebecca J. Morris
    Image of study
    TLDR Fluocinolone acetonide slows down hair follicle stem cells but speeds up skin cell growth in mice.
    In the 2007 study by Chebotaev et al., the effects of the glucocorticoid fluocinolone acetonide (FA) on stem cells in the hair follicle bulge and interfollicular epidermis of mice were examined. The results showed that keratinocytes in both areas express the glucocorticoid receptor, with those in the bulge having 30 to 40% higher expression. After FA treatment, bulge keratinocytes were slower to develop glucocorticoid resistance compared to interfollicular keratinocytes and did not significantly contribute to epidermal repair following skin atrophy within the 5-day study period. Interfollicular keratinocytes, on the other hand, downregulated the receptor and proliferated in response to FA. The commentary by R.J. Morris highlighted the need for longer studies to fully understand the response of hair follicle bulge keratinocytes.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 17 results

      community Minoxidil, fin, flaking scalp, and shedding hairs

      in Finasteride/Dutasteride  2 upvotes 5 years ago
      The user has been using Minoxidil and Finasteride since late 2019 with good results but is experiencing a dry, flaky scalp and shedding hairs. They also use Nizoral, biotin, zinc, magnesium, and collagen supplements, and their dermatologist prescribed fluocinolone acetonide to reduce flaking.

      community 2 months results minoxidil + finasteride

      in Treatment  331 upvotes 11 months ago
      User used topical minoxidil 5% with 0.1% finasteride twice daily, oral minoxidil 2.5mg, and finasteride 1mg daily, along with a hair multivitamin and weekly derma rolling. They missed the medication 3-4 times but still saw significant progress.

      community Questions about DUPA and figuring out what my hairloss is (NEED INPUT BADLY)

      in Finasteride/Dutasteride  4 upvotes 2 months ago
      The conversation discusses severe hair shedding and thinning, with the original poster using finasteride, oral minoxidil, and other supplements without improvement. The discussion highlights the possibility of telogen effluvium and the importance of addressing potential underlying health issues, such as stress and gut health, rather than assuming diffuse unpatterned alopecia (DUPA).
      16 advice on routine I’m beginning

      community 16 advice on routine I’m beginning

      in General  126 upvotes 1 month ago
      The user is experiencing hair thinning and bald spots, using Nizoral, rosemary oil, fluocinolone, and receiving PRP treatments. They are considering oral minoxidil and finasteride but are hesitant due to age and financial constraints.

    Related Research

    1 / 1 results