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    Glossary Epidermal Stem Cells

    specialized cells in the skin that regenerate and repair tissue

    Epidermal Stem Cells, also known as Skin Stem Cells, are specialized cells found in the outermost layer of the skin, the epidermis. These cells have the unique ability to self-renew and differentiate into various cell types that make up the epidermis, playing a crucial role in skin regeneration, wound healing, and maintaining the skin's barrier function.

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    1. Epidermal homeostasis: a balancing act of stem cells in the skin Nature Reviews Molecular Cell Biology · 2009 · 1039 citations
    2. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009 · 503 citations
    3. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011 · 396 citations
    4. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis Nature Communications · 2017 · 363 citations
    5. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Current Biology · 2001 · 338 citations
    6. Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development · 2003 · 182 citations
    7. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007 · 153 citations
    8. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    9. Epidermal stem cells in wound healing and their clinical applications Stem Cell Research & Therapy · 2019 · 129 citations
    10. Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells Stem cells · 2017 · 105 citations
    11. Human Eccrine Sweat Gland Cells Can Reconstitute a Stratified Epidermis Journal of Investigative Dermatology · 2010 · 103 citations
    12. The Human Hair Follicle: A Reservoir of CD40+ B7-Deficient Langerhans Cells that Repopulate Epidermis After UVB Exposure 1998 · 99 citations
    13. Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair Nature Communications · 2016 · 86 citations
    14. Epidermal stem cells and skin tissue engineering in hair follicle regeneration World Journal of Stem Cells · 2015 · 83 citations
    15. Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells International Journal of Molecular Sciences · 2013 · 83 citations
    16. Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay Journal of Investigative Dermatology · 2011 · 75 citations
    17. Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization Stem Cell Research & Therapy · 2020 · 65 citations
    18. Direct Effects of Minoxidil on Epidermal Cells in Culture Journal of Investigative Dermatology · 1984 · 63 citations
    19. Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells Development · 1996 · 61 citations
    20. Receptor activator of NF-κB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit Proceedings of the National Academy of Sciences of the United States of America · 2011 · 60 citations
    21. Lineage Analysis of Epidermal Stem Cells Cold Spring Harbor Perspectives in Medicine · 2014 · 57 citations
    22. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    23. Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy Cell death and differentiation · 2015 · 56 citations
    24. Electron Microscope Studies of the Human Epidermis The Clear Cell of Masson (Dendritic Cell or Melanocyte) The Journal of Cell Biology · 1958 · 56 citations
    25. 25 Years of Epidermal Stem Cell Research Journal of Investigative Dermatology · 2012 · 55 citations
    26. Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis. The International Journal of Developmental Biology · 2004 · 55 citations
    27. Epidermal cells: methods and protocols Melanoma Research · 2005 · 46 citations
    28. Progress in studies of epidermal stem cells and their application in skin tissue engineering Stem Cell Research & Therapy · 2020 · 44 citations
    29. Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors Stem Cells Translational Medicine · 2016 · 44 citations
    30. Differential sensitivity of epidermal cell subpopulations to β-catenin-induced ectopic hair follicle formation Developmental Biology · 2010 · 43 citations