TLDR Men with X-linked recessive ichthyosis often experience male-pattern baldness.
The study investigated the relationship between X-linked recessive ichthyosis (XRI) and male-pattern baldness, or androgenetic alopecia (AGA), in 26 patients. It found that 11 of these patients exhibited advanced stages of AGA. The research suggested that the deficiency in steroid sulfatase (STS) activity, which is characteristic of XRI, might influence testosterone metabolism and the development of AGA. The study proposed that the presence of two pathways for steroid biosynthesis, with the Δ5 pathway relying on steroid sulfate activity and the Δ4 pathway compensating in XRI males, could explain the occurrence of AGA in these individuals.
31 citations
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August 2001 in “PubMed” Hair follicles convert androgens, affecting hair loss patterns.
16 citations
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January 2000 in “Dermatology” 9 citations
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January 1999 in “Dermatology” Men with X-linked recessive ichthyosis may not experience typical male-pattern baldness.
179 citations
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December 1989 in “Medical Entomology and Zoology” Effective management of ichthyoses requires genetic counseling and appropriate treatments.
52 citations
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March 1987 in “Journal of the American Academy of Dermatology”
233 citations
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November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.
61 citations
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December 2001 in “Journal of Investigative Dermatology” Steroid sulfatase in hair follicles may be a target for treating hair loss.
9 citations
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January 1999 in “Dermatology” Men with X-linked recessive ichthyosis may not experience typical male-pattern baldness.
54 citations
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July 2002 in “Clinical and Experimental Dermatology” DHT, a testosterone byproduct, causes male pattern baldness.
103 citations
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June 2007 in “Endocrinology and Metabolism Clinics of North America” Male pattern hair loss is genetic and influenced by hormones, with treatments like minoxidil and surgery available.
