Male-Pattern Baldness in Men with X-Linked Recessive Ichthyosis

The study investigated the relationship between X-linked recessive ichthyosis (XRI) and androgenetic alopecia (AGA) in men, hypothesizing that men with XRI might not develop AGA or only mild forms of baldness due to a deficiency in steroid sulfatase (STS). A survey using the Hamilton-Norwood scale was conducted among 15 men diagnosed with XRI. The results showed a range of hair loss patterns, with 7 men at Hamilton-Norwood I, 3 at II, 3 at III-vertex, 1 at IV, and 1 at VII. These findings did not support the hypothesis that XRI and AGA are mutually exclusive, as advanced AGA was observed in some participants.