A Population-Based Nested Case-Control Study: The Use of 5-Alpha-Reductase Inhibitors and the Increased Risk of Osteoporosis Diagnosis in Patients with Benign Prostate Hyperplasia

    August 2014 in “ Clinical endocrinology ”
    Wen Ling Lin, Yi‐Ting Hsieh, Cheng Li Lin … Chia Hung Kao
    Studysummary This study suggests that the use of finasteride for benign prostate hyperplasia may increase the risk of osteoporosis diagnosis, particularly at higher doses.
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    Research cited in this study 9

    1. The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen, and Sexual Function in Healthy Young Men ˜The œJournal of urology/˜The œjournal of urology · 2008
    2. Changes in Hair Weight in Men with Androgenetic Alopecia After Treatment with Finasteride (1 mg Daily): Three- and Four-Year Results Journal of The American Academy of Dermatology · 2006
    3. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    4. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia The New England Journal of Medicine · 2003
    5. The Long-Term Effect of Specific Type II 5α-Reductase Inhibition With Finasteride on Bone Mineral Density in Men: Results of a 4-Year Placebo-Controlled Trial The Journal of Urology · 2002
    6. The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1998
    7. Reversible Severe Myopathy During Treatment with Finasteride Muscle & Nerve · 1997
    8. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992
    9. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992

    Related research 8

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    2. 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety Dermatologic Therapy · 2020
    3. Luncheon Symposium: Update on the Efficacy and Safety of Dutasteride in the Management of Androgenetic Alopecia 프로그램북(구 초록집) · 2015
    4. Comparative Effect of Finasteride and Dutasteride on Chromogranin A Levels Anticancer Research · 2010
    5. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    6. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    7. Effective Treatment of Female Androgenic Alopecia with Dutasteride PubMed · 2005
    8. Comparison of Clinical Trials with Finasteride and Dutasteride PubMed · 2004