Epigenetic Effects of Finasteride on Dopaminergic Signaling Pathways: A Potential Contributor to Post-Finasteride Syndrome
May 2024
in “
Physiology
”
finasteride dopaminergic signaling pathways epigenetic effects dopamine regulation dopamine secretion dopamine transport Phospholipase C-activating dopamine receptor signaling pathway dopaminergic synapse dopamine receptor activity dopamine receptor binding post-finasteride syndrome Propecia dopamine pathways epigenetics dopamine PFS
TLDR Finasteride may cause changes in dopamine-related genes, possibly leading to post-finasteride syndrome.
The study investigates the epigenetic effects of finasteride on dopaminergic signaling pathways by treating human Leydig cells with finasteride and identifying altered methylation in several genes involved in dopamine regulation. These changes were observed in genes related to dopamine secretion and transport, the Phospholipase C-activating dopamine receptor signaling pathway, the dopaminergic synapse, and dopamine receptor activity and binding. The findings suggest that altered epigenetic regulation of these pathways may contribute to the development of post-finasteride syndrome (PFS), warranting further investigation.
