Epigenetic Effects of Finasteride on Dopaminergic Signaling Pathways: A Potential Contributor to Post-Finasteride Syndrome
May 2024
in “
Physiology
”
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Studysummary This study examined the effects of finasteride on human Leydig cells and found altered methylation in dopaminergic pathways, suggesting potential epigenetic contributions to post-finasteride syndrome, warranting further investigation. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the epigenetic effects of finasteride on dopaminergic signaling pathways by treating human Leydig cells with finasteride and identifying altered methylation in several genes involved in dopamine regulation, secretion, and transport. These changes suggest that altered epigenetic regulation of dopaminergic pathways may contribute to the development of post-finasteride syndrome (PFS), warranting further investigation.
