This study examined the effects of finasteride on human Leydig cells and found altered methylation in dopaminergic pathways, suggesting potential epigenetic contributions to post-finasteride syndrome, warranting further investigation.
81 citations
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February 2019 in “Experimental & Molecular Medicine” This review examines PAK4 signaling pathways in prostate cancer, Parkinson's disease, and melanogenesis, focusing on the potential role of the PAK4-CREB axis, without reporting new clinical results.
10 citations
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August 2024 in “Neuroscience & Biobehavioral Reviews” This review discusses the role of neuro(active)steroids, particularly those in the 5α reductase pathway, in modulating dopamine signaling and their impact on neuropsychiatric disorders characterized by dopamine imbalances, including addiction, schizophrenia, and Parkinson's Disease.
April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that distinct neurons in the nucleus accumbens lateral shell regulate scratching behavior differently; D1R neurons promote scratching while D2R neurons help stop it, with elevated dopamine levels during chronic itch potentially enhancing persistent scratching.
January 2026 in “Food Science and Human Wellness” This research examined krill oil's effects on benign prostatic hyperplasia and found that it inhibited the growth of prostate cells in vitro and reduced prostate size and weight in a BPH rat model, suggesting potential as a prophylactic or therapeutic agent for BPH.