Sexual Dysfunction Related to Drugs: A Critical Review. Part V: Alpha-Blocker and 5-ARI Drugs

    November 2015 in “ Pharmacopsychiatry ”
    Antonio La Torre, Giancarlo Giupponi, Dearbhla Duffy, Andreas Conca, Tommaso Cai, A. Scardigli
    Image of study
    TLDR α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.
    This critical review examined the literature on sexual dysfunction as a side effect of drugs used to treat benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS), specifically focusing on α-blockers and 5-ARIs. The review highlighted that these drugs can cause erectile dysfunction, ejaculatory disorders, and reduced sexual desire, with silodosin among α-blockers having the highest incidence of ejaculatory issues. Persistent sexual side effects after discontinuing finasteride were noted, though further research is needed to understand this fully. The review emphasized the need for future studies to use validated tools to diagnose drug-induced sexual dysfunction and called for more research on the long-term effects of combining phosphodiesterase type 5 inhibitors with α-blockers or 5-ARIs. The review included studies published between 2002 and 2014, using resources from the APSS library in Trento, Italy.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    6 / 148 results

      community Fresh off the press: Dutasteride may cause chronic infertility

      in Research/Science  642 upvotes 2 weeks ago
      Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

      community NW5 at 19. How many grafts do I need?

      in Transplants  141 upvotes 1 year ago
      A 19-year-old with rapid hair loss since 16 is considering a hair transplant but refuses to take finasteride or any 5α-Reductase inhibitors. They are currently using minoxidil, tretinoin, and microneedling with a Derminator 2, and only want hair until age 27.

      community The truth about Dutasteride (w/ sources)

      in Finasteride/Dutasteride  52 upvotes 2 years ago
      The effectiveness of Dutasteride compared to Finasteride in treating hair loss, with evidence given such as studies and experiences, as well as discussion around whether one should switch from Finasteride to Dutasteride. There is also a discussion on post-Dutasteride syndrome.

      community "but it will hurt my gains bro"

      in Satire  1309 upvotes 6 months ago
      The conversation humorously discusses hair loss treatments like Minoxidil, Finasteride, and Dutasteride, and their effects on hair and muscle gains. Users debate effectiveness and side effects, mixing scientific approaches with jokes.

    Similar Research

    5 / 1000+ results