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GlossaryPDE5 inhibitors (phosphodiesterase type 5 inhibitors)

block enzyme to improve blood flow in certain conditions

PDE5 inhibitors, or phosphodiesterase type 5 inhibitors, are a class of medications that block the enzyme PDE5, which is involved in regulating blood flow in the body. By inhibiting this enzyme, these drugs help to relax blood vessels and improve blood flow, making them effective treatments for conditions like erectile dysfunction and pulmonary arterial hypertension.

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research 5-Alpha-Reductase Inhibitors and Combination Therapy

15 citations, July 2016 in “Urologic Clinics of North America”

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

research Sexual Dysfunction Related to Drugs: A Critical Review. Part V: Alpha-Blocker and 5-ARI Drugs

15 citations, November 2015 in “Pharmacopsychiatry”

α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.

research Lower Urinary Tract Symptoms: What’s New in Medical Treatment?

22 citations, January 2018 in “European urology focus”

New drugs and combination therapies are improving treatment for lower urinary tract symptoms.

research Medical Management of Benign Prostatic Hyperplasia

March 2024 in “Cleveland Clinic journal of medicine”

Alpha-blockers and 5-alpha reductase inhibitors are main treatments for BPH, with new support for phosphodiesterase-5 inhibitors and beta-3 agonists.

Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia

research Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia

35 citations, May 2020 in “Frontiers in Pharmacology”

Different drugs for prostate-related urinary symptoms work but have various side effects, and treatment should be tailored to the individual.

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