research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.
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research A New Look at the 5?-Reductase Inhibitor Finasteride
This review explores finasteride's effects on neuroactive steroid levels and their potential influence on disorders like depression and alcohol withdrawal but reports no new clinical findings.
research The biochemical and phenotypic characterization of females homozygous for 5 alpha-reductase-2 deficiency.
In this study, females with 5 alpha-reductase-2 deficiency exhibited decreased body hair, normal sebum production, and delayed menarche, suggesting a role for DHT in hair growth and menstrual function.
research 5 alpha-reductase-2 gene mutations in the Dominican Republic.
This study identified multiple mutations in the 5 alpha-reductase-2 gene among male pseudohermaphrodites in the Dominican Republic, suggesting they do not share a common ancestry.
research Selective non-steroidal inhibitors of 5α-reductase type 1
This review discusses the development and selectivity of 5 alpha-reductase inhibitors, particularly non-steroidal ones, and reports no new clinical trial results.
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5 / 1000+ resultscommunity 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?
Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.
community Does caffeine inhibit 5-α-reductase?
Caffeine may promote hair growth and potentially inhibit 5-α-reductase activity in hair follicles, but its effectiveness and systemic impact remain unclear. Users discuss using topical caffeine solutions, with some experiencing no side effects compared to finasteride.
community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction
Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.
community Which Saw Palmetto is good for blocking 5 alpha reductase, Serenoa repens or Chamaerops humilis?
The conversation is about determining which type of Saw Palmetto, either Chamaerops humilis or Serenoa repens, is effective for inhibiting the 5 alpha reductase enzyme related to hair loss. Specific treatments mentioned are Minoxidil, finasteride, and RU58841.
community Does anyone know about the mechanism between creatine and 5-alpha reductase?
Creatine may raise DHT levels, potentially affecting hair loss, but its exact mechanism is unclear. Some users report that finasteride remains effective even when taking creatine.
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10 / 15 results- Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.
- How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.
- Is the omega-3 to omega-6 ratio in your diet feeding your hair problem without you knowing? Nutrition sources describe a lopsided omega-6 to omega-3 intake as pro-inflammatory, but no published human study shows that the dietary ratio changes 5-alpha reductase, scalp DHT or hair loss; the one relevant trial tested a commercial omega-3/6 plus antioxidant supplement in 120 women, not a change in dietary fat ratio.
- Can Ecklonia Cava be used as a preventive treatment for early signs of hair thinning? No human trial has tested Ecklonia cava for hair loss, so it cannot be called preventive; the evidence is mouse studies and cell cultures suggesting antioxidant activity and 5-alpha-reductase inhibition in the lab.
- Does metformin help control DHT levels that trigger androgenic alopecia? Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.
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Frontline, gold standard treatment for combatting androgenic alopecia
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Heavy duty finasteride that comes with higher risks
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a natural and far less effective alternative to Finasteride
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acid used for antimicrobial, anti-inflammatory and anti-androgenic properties
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herb and oil with stimulant, circulatory, anti-inflammatory and antioxidant properties
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