Role of 5α-Dihydrotestosterone in Testicular Development of Gilthead Seabream Following Finasteride Administration

The study investigated the role of 5α-dihydrotestosterone (DHT) in the testicular development of gilthead seabream following finasteride administration. The researchers found that DHT triggers the onset of the meiotic phase of spermatogenesis and is involved in the regulation of 17ß-estradiol (E2) serum levels. They also found that serum levels of testosterone (T) regulate DHT serum levels by down-regulating the transcript levels of srd5a. The study suggests that DHT plays a physiologically important role in the regulation of spermatogenesis in some fish species.