Identification of 5α-Reductase Isoenzymes in Canine Skin

July 2015 in “ Veterinary Dermatology ”

Lucilene Bernardi de Souza, Manon Paradis, Gustavo Zamberlam, Marie-Odile Benoit-Biancamano, C. A. Price

5α-reductase 5αR1 5αR3 5αR2 alopecia X dutasteride finasteride mRNA Propecia Avodart

TLDR Two types of 5α-reductase are in dog skin, which might make dutasteride better than finasteride for treating dog hair loss.

The study investigated the expression of 5α-reductase isoenzymes in the skin of seven healthy beagles (three males, four females) to understand their role in alopecia X, a hair loss condition in dogs. It found that mRNA for 5αR1 and 5αR3 isoenzymes was present in canine skin, while 5αR2 was not detected. No significant differences were observed in the expression levels of these isoenzymes across different anatomical sites or between genders. These findings, which are the first to demonstrate the presence of 5αR3 in canine skin, suggest that dutasteride may be more effective than finasteride for treating alopecia X in dogs due to the low levels of 5αR2 and the inhibitory potency of dutasteride on 5αR3.

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research Effect of Dutasteride 0.5 mg/day in Men with Androgenetic Alopecia Recalcitrant to Finasteride

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Dutasteride helps hair growth in those unresponsive to finasteride, but may cause more sexual dysfunction.

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10 citations , July 2014 in “Veterinary dermatology”

Deslorelin may help intact male dogs regrow hair from alopecia X, with a 75% success rate and no side effects.

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97 citations , March 2014 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg works better than finasteride and placebo for increasing hair in men with hair loss.

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , January 2012 in “Advances in Urology”

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

research Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia

44 citations , June 2006 in “Biological & Pharmaceutical Bulletin”

Androgen hormones cause hair follicle scarring in hair loss, and finasteride helps reduce it.

research Adrenal Steroid Hormone Concentrations in Dogs with Hair Cycle Arrest (Alopecia X) Before and During Treatment with Melatonin and Mitotane

52 citations , October 2004 in “Veterinary dermatology”

Melatonin and mitotane treatment led to hair re-growth in 62% of dogs with Alopecia X, but this was not always linked to normal hormone levels.

research The 5alpha-Reductase Type 1, But Not Type 2, Gene Is Expressed in Anagen Hairs Plucked from the Vertex Area of the Scalp of Hirsute Women and Normal Individuals

17 citations , October 2003 in “Brazilian Journal of Medical and Biological Research”

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

research Androgenetic Alopecia in Women

139 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Androgenetic alopecia in women needs more research and better management strategies.

research Retrospective Evaluation of Sex Hormones and Steroid Hormone Intermediates in Dogs with Alopecia

34 citations , March 2003 in “Veterinary Dermatology”

Most dogs with alopecia had higher than normal levels of certain hormones, but hair loss might not always be linked to these hormone changes.

research Androgens and Alopecia

165 citations , December 2002 in “Molecular and Cellular Endocrinology”

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

research Clinical Application of 5α-Reductase Inhibitors

46 citations , March 2001 in “Journal of endocrinological investigation”

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human

193 citations , August 1985 in “Endocrinology”

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.