The 5alpha-Reductase Type 1, But Not Type 2, Gene Is Expressed in Anagen Hairs Plucked from the Vertex Area of the Scalp of Hirsute Women and Normal Individuals

    October 2003 in “ Brazilian Journal of Medical and Biological Research ”
    Isabel Oliveira, Cintia Lhullier, Ilma Simoni Brum, Poli Mara Spritzer
    Image of study
    TLDR The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.
    The study examined the expression of 5alpha-reductase type 1 (SDR5A1) and type 2 (SDR5A2) genes in the scalp hairs of 33 hirsute women (20 with polycystic ovary syndrome and 13 with idiopathic hirsutism), 10 men, and 15 normal women. Using RT-PCR, the researchers found that SDR5A2 was not expressed in any hair samples, and there were no significant differences in SDR5A1 expression among men, normal women, and hirsute women with or without polycystic ovary syndrome. The study concluded that SDR5A1 expression in the vertex area of the scalp does not contribute to the differences in hair growth seen between normal and hirsute individuals, suggesting that SDR5A1 is not the key enzyme affecting local androgen metabolism in scalp skin. The absence of SDR5A2 expression in the samples indicates that it may play a more significant role in hair growth and related conditions.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 255 results

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 8 months ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community Why does it seem everyone favors finasteride over dutasteride?

      in Female  62 upvotes 6 months ago
      The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

      community Hair loss causes are still a myth.

      in Chat  16 upvotes 3 years ago
      The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

    Related Research

    5 / 5 results