Development of a New Gas Chromatography–Mass Spectrometry Methodology for the Evaluation of 5α-Reductase Activity

    January 2013 in “ Talanta ”
    Cristina Amaral, Sara C. Cunha, José O. Fernandes … Georgina Correia‐da‐Silva
    Studysummary A new method was developed to accurately measure enzyme activity related to prostate health.
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    Research cited in this study 11

    1. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    2. Synthesis and Bioactivity of New Finasteride Conjugate Bioorganic & Medicinal Chemistry Letters · 2011
    3. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    4. 5α-Reductase Isozymes and Androgen Actions in the Prostate Annals of the New York Academy of Sciences · 2009
    5. In Vivo and In Vitro Effect of Novel 4,16-Pregnadiene-6,20-Dione Derivatives as 5α-Reductase Inhibitors The Journal of Steroid Biochemistry and Molecular Biology · 2008
    6. The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer ˜The œJournal of urology/˜The œjournal of urology · 2008
    7. Novel 5α-Reductase Inhibitors: Synthesis, Structure-Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids Journal of Medicinal Chemistry · 2005
    8. Determination Method for Steroid 5α-Reductase Activity Using Liquid Chromatography/Atmospheric Pressure Chemical Ionization–Mass Spectrometry Analytical Sciences · 2005
    9. Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5-Alpha-Reductase Inhibitors Chemical and Pharmaceutical Bulletin · 2005
    10. Synthesis and Evaluation of 2'-Substituted 4-(4'-Carboxy- or 4'-Carboxymethylbenzylidene)-N-Acylpiperidines: Highly Potent and In Vivo Active Steroid 5α-Reductase Type 2 Inhibitors Journal of Medicinal Chemistry · 2002
    11. FCE 28260, A New 5α-Reductase Inhibitor: In Vitro and In Vivo Effects The Journal of Steroid Biochemistry and Molecular Biology · 1996

    Related research 3

    1. Role of 5α-Reductase Inhibitors in Benign Prostatic Diseases Prostate cancer and prostatic diseases · 2012
    2. Effect of a Novel Steroid (PM-9) on the Inhibition of 5α-Reductase in Penicillium Crustosum Broths Steroids · 2003
    3. Finasteride The New England Journal of Medicine · 1994