Metabolic Dysfunction in Female Mice with Disruption of 5α-Reductase 1

    January 2017 in “ Journal of Endocrinology/Journal of endocrinology ”
    D Livingstone, Emma M. Di Rollo, Tracy C S Mak … Ruth Andrew
    Studysummary This study observed that female mice with disrupted 5α-reductase 1 showed increased insulin resistance and hepatic steatosis, suggesting altered glucocorticoid metabolism contributes to metabolic disorders.
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    Research cited in this study 3

    1. 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents Diabetes · 2014
    2. Role of 5α-Reductase Inhibitors in Androgen-Stimulated Skin Disorders PubMed · 2013
    3. Four-Amino Acid Segment in Steroid 5 Alpha-Reductase 1 Confers Sensitivity to Finasteride, a Competitive Inhibitor Journal of Biological Chemistry · 1992