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Glossary Adrenal Suppression

adrenal glands produce insufficient steroid hormones, especially cortisol

Adrenal Suppression, also known as Adrenal Gland Suppression, occurs when the adrenal glands produce insufficient amounts of steroid hormones, particularly cortisol. This condition can result from prolonged use of corticosteroid medications, which can inhibit the adrenal glands' natural hormone production. Symptoms may include fatigue, weakness, and low blood pressure, and it requires careful management to avoid serious health complications.

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Research

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research Hyperandrogenic eumenorrheic NON-PCOS women versus women with PCOS after the GnRH-agonist stimulation test preceded by suppression of adrenal steroidogenesis with dexamethasone

1 citations , September 2024 in “Journal of Clinical & Translational Endocrinology”

This study found that women with polycystic ovary syndrome have more pronounced metabolic alterations and higher androgen levels compared to women with eumenorrheic hyperandrogenism, suggesting EuHyperA may be a milder form of PCOS.

research Localized alopecia and suppression of hypothalamic-pituitary-adrenal (HPA) axis in dogs following treatment with difluprednate 0.05% ophthalmic emulsion (Durezol®)

2 citations , December 2021 in “BMC veterinary research”

This study found that long-term use of difluprednate ophthalmic emulsion in dogs can lead to HPA axis suppression and potentially cause iatrogenic hyperadrenocorticism, with localized alopecia suspected due to dermal absorption.

research Iatrogenic Cushing Syndrome and Secondary Adrenal Insufficiency Due to an Interaction Between Fluticasone and Ritonavir

1 citations , May 2021 in “Journal of the Endocrine Society”

This case report describes a woman with HIV who developed iatrogenic Cushing syndrome and adrenal insufficiency due to the interaction between fluticasone and ritonavir, highlighting the need for careful management of corticosteroid use in patients on protease inhibitors.

research Can Extra Adrenal Cortisol Secretion Occur in an Adrenalectomized Patient?

May 2021 in “Journal of the Endocrine Society”

This case study reports a patient with ACTH-driven cortisol secretion 14 years after adrenalectomy, suggesting possible residual adrenal tissue or extra-adrenal steroid synthesis, challenging the need for lifelong steroid replacement.

research Ovarian hyperthecosis coexisting with an incidental adrenal lesion: challenges in the diagnostic approach

May 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)”

This study describes a postmenopausal woman's diagnosis with ovarian hyperthecosis, confirmed by a GnRHa test normalizing testosterone, highlighting hormone therapy as a therapeutic option when surgery is not feasible.

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community EMA is re-examining Winlevi (clascoterone at lower concentration)

8 upvotes 1 year ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community CB-03-01 / Breezula Personal Results

17 upvotes 7 months ago

The user shared their experience with CB-03-01 (Breezula/Clascoterone) for hair loss, noting reduced shedding and improved hair appearance but experiencing significant sleep disturbances and low energy due to HPA axis suppression. They decided to stop using it due to these side effects and are waiting for GT20029 as an alternative.

community There’s actually a quite good chance that next year, we might see a new treatment get FDA approval for the first time in nearly three decades.

78 upvotes 1 year ago

Breezula, a potential new hair loss treatment, may receive FDA approval soon, but it is expected to be a weaker alternative to finasteride and minoxidil. Concerns include its twice-daily application and possible side effects like HPA axis suppression.

community Almost 4 months, before and after of pyrilutamide .5% once daily

23 upvotes 4 months ago

The user experienced significant hair regrowth using a combination of minoxidil, alfatradiol, pyrilutamide, and nizoral, despite previous intolerance to finasteride. They emphasize the importance of consistency in treatment and are optimistic about the results, noting no side effects so far.

community Dutasteride is not maintaining my hair. What are some other good options?

in Treatment 2 upvotes 11 months ago

The user is experiencing diffuse hair loss despite using finasteride and dutasteride and is considering adding minoxidil, microneedling, or RU58841. They are also thinking about increasing the dutasteride dose or opting for a hair transplant, while being cautious about side effects.

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