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This study investigated pyranoanthocyanin Vitisin A and found it significantly lowered triglyceride levels and reduced body weight in high-fat diet-fed mice, outperforming Cyanidin-3-O-glucoside by inhibiting hepatic lipogenesis and enhancing fatty acid β-oxidation.

This study found that mice lacking myelin protein zero-like 3 (Mpzl3) had reduced body weight and adiposity despite increased food intake, which was linked to higher energy expenditure and improved glycemic control.

This study observed that female mice with disrupted 5α-reductase 1 showed increased insulin resistance and hepatic steatosis, suggesting altered glucocorticoid metabolism contributes to metabolic disorders.

In this study, finasteride significantly reduced plasma cholesterol and triglycerides and decreased atherosclerotic lesion burden in mice, suggesting its potential role in delaying cardiovascular disease.

This study found that male 5αR1 knockout mice and obese Zucker rats treated with finasteride showed increased insulin resistance and hepatic steatosis, potentially implicating 5α-reductase activity in metabolic liver disease development.