Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome

    September 2023 in “ ˜The œJournal of clinical endocrinology and metabolism ”
    Jia Zhu, Anders U. Eliasen, Izzuddin M. Aris, Sara Stinson, Jens-Christian Holm, Torben Hansen, Marie‐France Hivert, Klaus Bønnelykke, Rany M. Salem, Joel N. Hirschhorn, Yee-Ming Chan
    Image of study
    TLDR Genetic risk for PCOS can affect children's growth, metabolism, and development from early life into adulthood.
    The study involved 12,350 children and found that genetic risk factors for Polycystic ovary syndrome (PCOS) are associated with changes in metabolic, growth, and developmental traits in childhood. A higher PCOS polygenic risk score (PRS) was linked with a higher body mass index in midchildhood (0.05 kg/m2 increase per 1 SD of PRS) and a higher risk of obesity in early childhood (OR 1.34). It was also associated with earlier age at pubarche (0.85-month decrease per 1 SD of PRS) and younger age at peak height velocity (0.64-month decrease per 1 SD of PRS). The study also found that a child's PCOS PRS has direct effects on childhood outcomes, independent of the mother's polygenic risk for PCOS. These effects include significant associations with metabolic, growth, and developmental outcomes from midchildhood to late adolescence. The study concluded that genetic liability for PCOS can result in alterations in metabolic, growth, and developmental traits in both sexes starting in early life and extending into adulthood.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 12 results

      community How does hair loss and recovery work?

      in Chat  12 upvotes 2 months ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  56 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community Why balding gets worse in every generation?

      in Chat  81 upvotes 5 months ago
      Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

    Related Research

    1 / 1 results