Analysis of 72,469 UK Biobank Exomes Links Rare Variants to Male-Pattern Hair Loss

    September 2023 in “ Nature Communications ”
    S. Henne, Rana Aldisi, Sugirthan Sivalingam … Markus M. Nöthen
    Studysummary In this study, the researchers found that rare genetic variants make a minor contribution to male-pattern hair loss risk, identifying five significant gene associations, including novel genes, and noting a shared basis with monogenic hair loss disorders.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on nature.com →
    Discuss this study in the Community →

    Research cited in this study 29

    1. Male-Pattern Hair Loss: Comprehensive Identification of the Associated Genes as a Basis for Understanding Pathophysiology Medizinische Genetik · 2023
    2. Evidence for a Functional Interaction of WNT10A and EBF1 in Male-Pattern Baldness PLoS ONE · 2021
    3. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    4. Mapping of Cis-Acting Expression Quantitative Trait Loci in Human Scalp Hair Follicles BMC Dermatology · 2020
    5. Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies Experimental Dermatology · 2020
    6. Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness Nature Communications · 2018
    7. GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk Nature Communications · 2017
    8. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    9. Genetic Prediction of Male Pattern Baldness PLoS Genetics · 2017
    10. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
    11. A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features Nature Communications · 2016
    12. Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us? Experimental Dermatology · 2016
    13. Hair Growth Promoting Potential of Phospholipids Purified from Porcine Lung Tissues Biomolecules & Therapeutics · 2015
    14. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    15. To Grow or Not to Grow: Hair Morphogenesis and Human Genetic Hair Disorders Seminars in Cell & Developmental Biology · 2013
    16. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    17. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    18. Unveiling the Roots of Monogenic Genodermatoses: Genotrichoses as a Paradigm Journal of Investigative Dermatology · 2011
    19. Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness British Journal of Dermatology · 2011
    20. Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin Journal of Biological Chemistry · 2011
    21. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    22. Fine Mapping of the Human AR/EDA2R Locus in Androgenetic Alopecia British Journal of Dermatology · 2010
    23. Recent Positive Selection of a Human Androgen Receptor/Ectodysplasin A2 Receptor Haplotype and Its Relationship to Male Pattern Baldness Human Genetics · 2009
    24. Androgen Receptor Copy Number Variation and Androgenetic Alopecia: A Case-Control Study PLOS ONE · 2009
    25. Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11 Nature Genetics · 2008
    26. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    27. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    28. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    29. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003