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GlossaryEctodysplasin A2 Receptor (EDA2R)

regulates development of skin, hair, and ectodermal tissues

The Ectodysplasin A2 Receptor (EDA2R) is a protein found on the surface of certain cells that plays a crucial role in the development of skin, hair, and other ectodermal tissues. Mutations in the gene encoding this receptor can lead to conditions like ectodermal dysplasia, which can result in abnormalities in hair growth, skin texture, and dental development.

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research EDA2R Is Associated With Androgenetic Alopecia

82 citations, September 2008 in “Journal of Investigative Dermatology”

EDA2R gene linked to hair loss.

research P53-Dependent Transcriptional Regulation of EDA2R and Its Involvement in Chemotherapy-Induced Hair Loss

37 citations, April 2010 in “FEBS Letters”

The study concludes that the EDA2R gene is activated by p53 during chemotherapy but is not necessary for chemotherapy-induced hair loss.

research Fine Mapping of the Human AR/EDA2R Locus in Androgenetic Alopecia

28 citations, April 2010 in “British Journal of Dermatology”

Genetic marker rs12558842 strongly linked to male hair loss.

A Tale of Two Haplotypes: The EDA2R/AR Intergenic Region Is the Most Divergent Genomic Segment Between Africans and East Asians in the Human Genome

research A Tale of Two Haplotypes: The EDA2R/AR Intergenic Region Is the Most Divergent Genomic Segment Between Africans and East Asians in the Human Genome

4 citations, December 2012 in “Human Biology”

The most different genetic segment between Africans and East Asians is the EDA2R/AR region, with two main types influenced by population changes and natural selection, and linked to baldness.

research Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss

38 citations, February 2012 in “British Journal of Dermatology”

AR/EDA2R gene linked to early-onset female hair loss, but 20p11 gene not involved.

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community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 6 months ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.