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Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Mutations in certain receptors can cause diseases and offer new treatment options.

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Skin health and diseases are closely linked to metabolic processes.

The SOSTDC1 gene is crucial for determining sheep wool type.

Ectoin helps prevent cortisone-induced skin problems and supports skin health.

The glucocorticoid receptor helps protect skin from tumors and other issues.

Hormones and genes affect hair growth and male baldness.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Gene expression in hair follicles can help diagnose methamphetamine use disorder.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

Editing the FGF5 gene in sheep increases fine wool growth.

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

Genomic approach finds new possible treatments for hair loss.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.