Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor

    December 2016 in “ Springer eBooks ”
    Nicolas C. Nicolaides, Agaristi Lamprokostopoulou, Amalia Sertedaki … Evangelia Charmandari
    Studysummary This review examines the clinical features, causes, diagnosis, and treatment of Chrousos syndrome but reports no new experimental findings on this condition.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 5

    1. Chrousos Syndrome: From Molecular Pathogenesis to Therapeutic Management European Journal of Clinical Investigation · 2015
    2. Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor BMC Endocrine Disorders · 2014
    3. Primary Generalized Glucocorticoid Resistance And Hypersensitivity Hormone Research in Paediatrics · 2011
    4. A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005
    5. Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2002