Non-Canonical Dimerization of the Androgen Receptor and Other Nuclear Receptors: Implications for Human Disease

The document reviewed recent advances in understanding the structure-and-function relationship of steroid nuclear receptors, particularly focusing on the androgen receptor (AR) and its dysregulation in prostate cancer (PCa) and androgen insensitivity syndromes (AIS). It also discussed conditions linked to mutations in the glucocorticoid receptor (GR) gene and the thyroid hormone receptor (TR). The review highlighted the implications of these findings for the etiology of human diseases and explored potential novel and selective therapeutic strategies based on these insights.