Non-Canonical Dimerization of the Androgen Receptor and Other Nuclear Receptors: Implications for Human Disease

    June 2019 in “ Endocrine Related Cancer ”
    Alba Jiménez-Panizo, Paloma Pérez, Ana M. Rojas, Pablo Fuentes‐Prior, Eva Estébanez‐Perpiñá
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    TLDR Mutations in certain receptors can cause diseases and offer new treatment options.
    The document reviewed recent advances in understanding the structure-and-function relationship of steroid nuclear receptors, particularly focusing on the androgen receptor (AR) and its dysregulation in prostate cancer (PCa) and androgen insensitivity syndromes (AIS). It also discussed conditions linked to mutations in the glucocorticoid receptor (GR) gene and the thyroid hormone receptor (TR). The review highlighted the implications of these findings for the etiology of human diseases and explored potential novel and selective therapeutic strategies based on these insights.
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