From Gene to Therapy in Spinal and Bulbar Muscular Atrophy: Are We There Yet?

    July 2017 in “ Molecular and Cellular Endocrinology ”
    Maria Pennuto, Pasquale Striano
    Studysummary The authors reviewed the mechanisms behind Kennedy's disease, noting advances in therapeutic strategies such as androgen deprivation and gene silencing that may soon expand treatment options for this incurable neuromuscular condition.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 3

    1. Early Onset and Novel Features in a Spinal and Bulbar Muscular Atrophy Patient with a 68 CAG Repeat Neuromuscular Disorders · 2014
    2. Men With Kennedy Disease Have a Reduced Risk of Androgenetic Alopecia British Journal of Dermatology · 2007
    3. Intermolecular NH2-/Carboxyl-Terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity Journal of biological chemistry/˜The œJournal of biological chemistry · 1998

    Related research 2

    1. Early Onset and Novel Features in a Spinal and Bulbar Muscular Atrophy Patient with a 68 CAG Repeat Neuromuscular Disorders · 2014
    2. Spinal and Bulbar Muscular Atrophy: Pathogenesis and Clinical Management Oral Diseases · 2013