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GlossaryAndrogen Insensitivity Syndrome (AIS)

genetic condition causing resistance to male hormones in XY individuals

Androgen Insensitivity Syndrome (AIS) is a genetic condition where a person who is genetically male (with one X and one Y chromosome) is resistant to male hormones called androgens. As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man. This can lead to a range of physical manifestations, from completely typical female external genitalia to ambiguous genitalia, depending on the degree of insensitivity.

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research Clinical, Hormonal, Behavioral, and Genetic Characteristics of Androgen Insensitivity Syndrome in a Brazilian Cohort: Five Novel Mutations in the Androgen Receptor Gene

174 citations, July 2003 in “The Journal of Clinical Endocrinology & Metabolism”

Five new mutations in the androgen receptor gene were found, helping to understand androgen insensitivity syndrome better.

research Fulvestrant: A New Treatment Option for Advanced Breast Cancer - Tolerability Versus Existing Agents

67 citations, October 2005 in “Annals of Oncology”

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

research Androgen Receptors And Their Biology

66 citations, January 2001 in “Vitamins and hormones”

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

research Intravaginal Testosterone Improves Sexual Satisfaction and Vaginal Symptoms Associated With Aromatase Inhibitors

37 citations, September 2018 in “The Journal of Clinical Endocrinology and Metabolism”

Intravaginal testosterone cream improves sexual satisfaction and reduces vaginal discomfort in postmenopausal women on breast cancer treatment without affecting hormone levels.

research Non-Canonical Dimerization of the Androgen Receptor and Other Nuclear Receptors: Implications for Human Disease

25 citations, June 2019 in “Endocrine Related Cancer”

Mutations in certain receptors can cause diseases and offer new treatment options.

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community Losing grond with fin/min. Should I keep going?

in Satire 372 upvotes 1 year ago

Hair loss treatments, specifically trying Minoxidil and finasteride combined with other methods such as microneedling and diet changes. Suggestions for coping strategies have also been offered.

community What to do about High E2 levels on Finasteride?

in Treatment 6 upvotes 2 years ago

User experienced high E2 levels after taking finasteride and sought advice on lowering E2 with supplements like Tonkat ali, Fadogia, and Boron. They also used DIM, zinc, and magnesium but avoided using an AI.

community Did pre-tests before starting finasteride, turns out I have abnormally high estrogen

in Finasteride/Dutasteride 1 upvotes 3 months ago

A 23-year-old with high estrogen levels is considering starting finasteride for hair loss and plans to use a low dose topical treatment while also seeking to lower estrogen levels. They will consult an endocrinologist for further guidance.

community Just started RU a month ago after being on fin and min for almost 3 years. Progress so far: My temples were pretty bare before this. Really hoping at least some of these become terminal.

in Is this regrowth? 396 upvotes 7 months ago

A user started using RU58841 a month ago after using finasteride and minoxidil for nearly three years, hoping for hair regrowth at the temples. Other users suggest vitamin B supplements and microneedling to improve hair thickness, and one mentions the possibility of a hair transplant for the temples.

community I don't know what happened with me sudden hair loss from 6 months i use dut ,min , vitamin all things but no response

in Progress Pictures 18 upvotes 1 year ago

The person is experiencing sudden hair loss for six months and treatments like dutasteride, minoxidil, and vitamins are not working. Another person suggests the hair loss might not be androgenetic alopecia but could be telogen effluvium or an inflammatory condition.

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