Endocrinopathies and Other Disorders Inducing a Polycystic Ovary Syndrome Phenotype

    October 2012 in “ S. Karger AG eBooks
    Krystallenia I. Alexandraki, Gregory Kaltsas
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    TLDR Some conditions mimic PCOS symptoms and need careful diagnosis to treat potentially serious health issues.
    The document from 2012 examines conditions that can present with symptoms similar to Polycystic Ovary Syndrome (PCOS), a common endocrine disorder in premenopausal women. It emphasizes the importance of differentiating PCOS from other life-threatening disorders that mimic its clinical presentation, such as adrenal and ovarian tumors, steroidogenic deficiencies, and various medical or endocrine conditions. The prevalence of these disorders in women with PCOS-like symptoms is less than 7%, but they require prompt diagnosis and treatment due to their potential morbidity or mortality. The document also explores the pathogenesis of PCOS, suggesting it is influenced by genes regulating the hypothalamo-pituitary-ovarian axis and insulin resistance, with insulin and luteinizing hormone (LH) enhancing androgen production. Additionally, it discusses the association of conditions like Cushing's Syndrome, hyperprolactinemia, thyroid dysfunction, acromegaly, and hyperinsulinemia with PCOS-like symptoms. The document concludes that while most women with hyperandrogenism and chronic anovulation have PCOS, a careful differential diagnosis is crucial for identifying and treating other disorders that can present similarly, especially in the context of insulin resistance and hyperinsulinemia.
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