Glucocorticoid Resistance Syndrome in Two Patients With Diverse Genotype

The study examines Glucocorticoid Resistance Syndrome (GRS) in two patients, emphasizing the genetic diversity and diagnostic challenges of the condition. Patient A, a 66-year-old woman, had neuropsychiatric symptoms and hypercortisolism but no NR3C1 gene variant; her symptoms improved with low-dose dexamethasone. Patient B, a 43-year-old woman, had a novel NR3C1 variant and similar symptoms, with stable condition under monitoring. The study highlights the complexity of diagnosing and managing GRS due to its broad clinical spectrum and genetic variability, suggesting the importance of NR3C1 sequencing and focusing on suppressing the HPA axis in management.