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GlossaryCushing's syndrome (Hypercortisolism)

condition caused by excessive cortisol, leading to weight gain and skin changes

Cushing's syndrome, also known as hypercortisolism, is a condition characterized by prolonged exposure to high levels of cortisol, a hormone produced by the adrenal glands. This can result from taking corticosteroid medications or from the body producing too much cortisol due to tumors in the pituitary or adrenal glands. Symptoms include weight gain, particularly around the abdomen and face, thinning skin, easy bruising, and in some cases, hair loss or excessive hair growth.

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research Prevalence of Systemic Hypertension and Control of Systolic Blood Pressure in a Cohort of 14 Dogs with Adrenal-Dependent Hypercortisolism During the First Year of Trilostane Treatment or After Adrenalectomy

February 2024 in “Animals”

Most dogs with adrenal-dependent hypercortisolism had normal blood pressure after one year of treatment or surgery.

research Apparent Cortisone Reductase Deficiency: A Rare Cause of Hyperandrogenemia and Hypercortisolism

41 citations , January 2000 in “Hormone Research in Paediatrics”

Cortisone reductase deficiency can cause high androgen and cortisol levels and may be missed in women with similar symptoms.

$Age-Dependent Endocrine Disorders Involved in the Pathogenesis of Refractory Acne in Women$

research Age-Dependent Endocrine Disorders Involved in the Pathogenesis of Refractory Acne in Women

24 citations , November 2016 in “Molecular Medicine Reports”

Hormonal imbalances, often indicating conditions like PCOS, are common in women with hard-to-treat acne, and a treatment approach addressing these imbalances may be needed.

research Pregnancy During the Course of Cushing’s Syndrome: A Case Report and Literature Review

9 citations , April 2020 in “Endocrinology, diabetes & metabolism case reports”

Pregnancy with Cushing's syndrome is rare and risky for both mother and baby, needing early diagnosis and treatment.

research When the Cure Becomes the Cause: Adrenal Insufficiency in Cushing's Management

October 2025 in “Journal of the Endocrine Society”

Careful dosing and monitoring are crucial to prevent adrenal insufficiency when using ketoconazole for Cushing's disease.

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community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

in Female 42 upvotes 4 years ago

User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.