3 citations
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December 2017 in “Journal of Psychiatric Research” This study found that hair cortisol did not indicate expected hypercortisolism in acutely underweight anorexia nervosa patients and did not change significantly during short-term weight restoration.
30 citations
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January 2001 in “Journal of the American Veterinary Medical Association” This study found that adrenal sex hormone levels were elevated in neutered dogs with hypercortisolemia, except for testosterone, highlighting the importance of ruling out hypercortisolemia when diagnosing adrenal hyperplasia syndrome.
1 citations
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February 2025 in “Journal of Endocrinological Investigation” This review discusses the prevalence and clinical impact of menstrual abnormalities, acne, and hirsutism in young women with Cushing's syndrome and reports no new clinical results.
April 2026 in “Almanac of Clinical Medicine” In this study, pemphigus vulgaris patients treated with high-dose prednisolone developed symptoms similar to those seen in corticosteroma, such as weight gain and muscle weakness, with increased risks of arterial hypertension and glucose metabolism disorders after 6 months of therapy.
March 2026 in “Lithuanian University of Health Sciences” In this case report, a rare instance of ACTH-independent hypercortisolism in a patient with long-standing Addison's disease led to the discovery of an adrenal cortical adenoma, successfully treated with adrenalectomy, underscoring the importance of considering functional adrenal tumors in such atypical biochemical scenarios.
February 2024 in “Animals” In this study, dogs with adrenal-dependent hypercortisolism showed a decrease in the prevalence of systemic hypertension from 79% to 25% after a year of trilostane treatment or adrenalectomy, with blood pressure normalization observed by three months post-surgery in hypertensive dogs.
41 citations
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January 2000 in “Hormone Research in Paediatrics” In this case study, a 55-year-old woman with androgenetic alopecia was ultimately diagnosed with hepatic cortisone reductase deficiency after initially suspected 21-hydroxylase deficiency was ruled out.
217 citations
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July 2009 in “Experimental and Clinical Endocrinology & Diabetes” This study found that hair cortisol levels were significantly higher in patients with Cushing's Syndrome compared to healthy controls, suggesting hair analysis can provide historical information on cortisol exposure.
175 citations
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January 2020 in “European Journal of Endocrinology” These guidelines recommend testing thyroid function in patients with obesity due to common hypothyroidism, and highlight that weight loss is crucial for addressing hormonal imbalances, with only modest weight loss benefits from treating endocrine disorders.
24 citations
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November 2016 in “Molecular Medicine Reports” This study found that women with acne resistant to conventional treatments had significantly higher levels of testosterone, DHEA‑S, prolactin, and LH, suggesting potential underlying hormonal disorders.
10 citations
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December 1992 in “PubMed” This report of three cases found that diagnosing hypercortisolism during pregnancy can be challenging, but early detection using unbound steroid levels and MRI could prevent severe complications.
9 citations
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April 2020 in “Endocrinology, diabetes & metabolism case reports” This case study highlights the significance of early diagnosis and treatment of Cushing's syndrome during pregnancy, as it is associated with severe maternal and fetal complications, including stillbirth.
1 citations
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September 2020 in “Endocrinology, Diabetes & Metabolism Case Reports” This case report describes a woman with hypertension, alopecia, and other symptoms, revealing that her condition was due to ovarian hyperthecosis, highlighting the overlap of adrenal and ovarian disorders.
April 2026 in “Veterinary Medicine and Science” In this case report, authors described a pet golden hamster with a confirmed adrenocortical adenocarcinoma, where laboratory testing and diagnostic imaging enabled antemortem diagnosis, despite the species' rarity for these procedures.
October 2025 in “Journal of the Endocrine Society” In this case study, a 69-year-old woman with severe hypercortisolism developed acute adrenal insufficiency after starting ketoconazole treatment, highlighting the need for cautious dosing and close monitoring of adrenal function, particularly in patients with prior glucocorticoid exposure.
May 2025 in “Journal of the ASEAN Federation of Endocrine Societies” This case study highlights a testosterone- and cortisol-secreting adrenal oncocytic neoplasm in an 18-year-old woman, illustrating the role of surgical excision in resolving hyperandrogenism and restoring menstruation.
February 2025 in “La Pediatria Medica e Chirurgica” In this case study, a 12-year-old boy with Cushing's Disease experienced a complex diagnostic journey; ultimately, a left-side ACTH-secreting microadenoma was identified and treated with gamma knife therapy, normalizing hypercortisolism but resulting in growth hormone deficiency.
January 2025 in “JCEM Case Reports” This report describes two cases of glucocorticoid resistance syndrome highlighting genetic diversity; one patient improved with low-dose dexamethasone despite negative genetic testing, while the other is monitored with a novel NR3C1 variant.
April 2024 in “JCEM case reports” In this case study, a 44-year-old woman with an adrenal adenoma secreting both cortisol and androgens developed Cushing syndrome and significant virilization, but experienced major symptom improvement following surgical removal of the benign tumor.
October 2023 in “Journal of the Endocrine Society” This case report describes a challenging diagnosis of Cushing’s syndrome using endocrine tests and imaging, which ultimately identified an adrenal etiology. Successful treatment involved a non-invasive desmopressin stimulation test and right adrenalectomy, leading to improvement in symptoms and health outcomes for the patient.
April 2020 in “Journal of the Endocrine Society” This study suggests that hair cortisol measurement could serve as an alternative diagnostic method for Cushing’s disease, showing acceptable concordance with urinary free cortisol despite differing evaluated periods.
April 2020 in “Journal of the Endocrine Society” In this case study, the use of somatostatin analogues was effective in localizing and confirming a neuroendocrine lung tumor as the source of ectopic ACTH syndrome, leading to marked clinical improvement in a patient unable to undergo surgery.
January 2024 in “The American journal of medicine” In this case report, the authors describe the first documented occurrence of new-onset hypocortisolism after laparoscopic sleeve gastrectomy in a patient, highlighting the need for awareness of this condition among clinicians when patients present with nonspecific symptoms post-bariatric surgery.
November 2022 in “Journal of the Endocrine Society” This case report describes a patient with ectopic Cushing's syndrome who experienced fatal complications from COVID-19, highlighting the challenges in managing such patients due to immune response alterations from endogenous hypercortisolemia.
October 2023 in “Journal of the Endocrine Society” This case report highlights the potential benefits of unilateral adrenalectomy in treating primary bilateral macronodular adrenal hyperplasia, noting a high rate of remission and low risk of recurrence.
March 2023 in “European journal of internal medicine” This case study highlights a delayed diagnosis of Sheehan's syndrome in a woman with post-partum hemorrhage history, emphasizing the importance of considering non-specific symptoms and menstrual history for diagnosis.
5 citations
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February 2023 in “European journal of endocrinology” This study found that older patients with Cushing's syndrome had fewer typical symptoms of hypercortisolism, more comorbidities, and were more often treated conservatively compared to younger patients.
16 citations
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September 2009 in “Schweizer Archiv für Tierheilkunde” This case report describes an 8-year-old Russian Blue cat with bilateral adrenal carcinomas secreting high levels of progesterone, showing symptoms similar to hypercortisolism.
October 2023 in “Journal of the Endocrine Society” This study reported a rare case where a pheochromocytoma produced ACTH, leading to cyclic Cushing syndrome, and underscores the importance of considering this possibility in cases of ACTH-dependent hypercortisolism with an adrenal mass.
November 2022 in “Journal of the Endocrine Society” This case report suggests that genetic evaluation for glucocorticoid resistance, such as the NR3C1 gene variant, is crucial for proper diagnosis and management of patients showing atypical signs of hypercortisolism.