TLDR Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.
The document from 1992 provides a comprehensive review of the biology and clinical application of systemic glucocorticoids. It covers their molecular structure, receptor binding, and effects on gene expression, as well as their physiological roles in regulating various bodily systems. The paper discusses the pharmacology of glucocorticoids, including their absorption, metabolism, and excretion, and outlines their therapeutic use in a wide range of inflammatory diseases. It also addresses the potential adverse effects of glucocorticoids, such as osteoporosis, growth suppression in children, and neuropsychiatric changes, and emphasizes the importance of using the lowest effective dose to minimize these risks. The document concludes that while glucocorticoids are potent anti-inflammatory agents, their use requires careful management to balance the benefits against the potential for serious side effects.
18 citations,
January 1990 in “Journal of The American Academy of Dermatology” Lower doses of dexamethasone can safely reduce high DHEAS levels in women with androgenic disorders.
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January 2024 in “Journal der Deutschen Dermatologischen Gesellschaft” Non-biologic immunosuppressive drugs are crucial for treating autoimmune and chronic inflammatory skin diseases.
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14 citations,
July 2021 in “Reviews in endocrine and metabolic disorders” SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.
14 citations,
September 2015 in “Expert Opinion on Therapeutic Targets” The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.
3 citations,
January 2016 in “Elsevier eBooks” Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.
9 citations,
July 2020 in “Experimental Dermatology” Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
