Non-Polycystic Ovary Syndrome–Related Endocrine Disorders Associated with Hirsutism

    Kürşad Ünlühizarcı, Gregory Kaltsas, Fahrettin Keleştimur
    Image of study
    TLDR Hirsutism can be caused by various conditions besides PCOS, and it's important to treat the underlying issue and manage symptoms with medication and cosmetic approaches.
    The document reviews the causes and treatments of hirsutism not related to polycystic ovary syndrome (PCOS), emphasizing that while PCOS is the most common cause, other conditions like nonclassical adrenal hyperplasia, idiopathic hirsutism, HAIR-AN syndrome, and various endocrine disorders can also lead to hirsutism. It discusses the role of androgens in hair growth, the importance of diagnosing and treating underlying conditions, and the potential cardiovascular risks associated with hyperandrogenism. Treatments include pharmacological options such as antiandrogens, oral contraceptives, gonadotrophin-releasing hormone agonists, insulin sensitizers, and cosmetic measures. The document notes that low-dose finasteride is as effective as high-dose therapy for hirsutism, and spironolactone can be combined with finasteride for improved outcomes. It also mentions the importance of using effective contraception with finasteride due to its teratogenic potential. The document stresses the need for individualized treatment plans and the importance of recognizing hirsutism as a sign of potentially serious conditions. It does not provide specific numbers of study participants, so the strength of the evidence cannot be assessed.
    Discuss this study in the Community →

    Research cited in this study

    24 / 24 results

    Related Community Posts Join

    6 / 24 results

      community AA and Hirsutism but T levels are normal

      in Female  8 upvotes 3 years ago
      27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

      community No, Finasteride as a treatment for MPB was not an "accident"

      in Research/Science  105 upvotes 3 years ago
      Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

      community Coegin Pharma to release Follicopeptide (FOL005) by Q2 2025

      in Treatment  117 upvotes 2 months ago
      Follicopeptide (FOL005) by Coegin Pharma will launch as a cosmetic hair growth treatment by Q2 2025, showing similar efficacy to finasteride. Users discuss the benefits and skepticism of releasing hair loss treatments as cosmetics rather than drugs.

      community Does low HGH leading to hairloss?

      in Research/Science  13 upvotes 9 months ago
      The user experiencing diffuse hair loss is using various treatments including RU58841, finasteride, minoxidil with tretinoin, anti-hair loss shampoo, and microneedling, and is considering adding peptides TB500, BPC157, and GHK-Cu. They have low growth hormone levels and are questioning its impact on hair loss, while another user suggests androgenic alopecia and androgens are likely the main cause of hair loss.

      community Any balding females? I need advice with coping :(

       16 upvotes 8 years ago
      A 27-year-old woman is struggling with hair loss, feeling self-conscious and seeking advice on coping. She mentions trying Minoxidil but is hesitant due to scalp issues and is looking for ways to regain confidence.

    Related Research

    4 / 4 results