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GlossaryNon-Classical Adrenal Hyperplasia

partial enzyme deficiency causing excess androgen production

Non-Classical Adrenal Hyperplasia (NCAH) is a milder form of congenital adrenal hyperplasia that typically presents later in life, often during adolescence or adulthood. It is caused by a partial deficiency in the enzyme 21-hydroxylase, leading to an overproduction of androgens (male hormones). Symptoms can include irregular menstrual cycles, excessive hair growth (hirsutism), and acne in females, while males may experience early signs of puberty.

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research Non-Polycystic Ovary Syndrome–Related Endocrine Disorders Associated with Hirsutism

39 citations, May 2011 in “European Journal of Clinical Investigation”

Hirsutism can be caused by various conditions besides PCOS, and it's important to treat the underlying issue and manage symptoms with medication and cosmetic approaches.

research Hormonal Acne: Leading to a Paradigm Shift in the Management of Acne

June 2013 in “Expert Review of Dermatology”

The article concludes that hormonal therapy is an effective long-term acne treatment, even for those without hormonal imbalances.

research Clinical Relevance of Testosterone and Dihydrotestosterone Metabolism in Women

31 citations, January 1995 in “The American journal of medicine”

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

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