CRH Receptor Antagonists From Pulsatilla Chinensis Prevent CRH-Induced Premature Catagen Transition In Human Hair Follicles

February 2020 in “ Journal of Cosmetic Dermatology ”

You Jin Nam, Eun Young Lee, Eun‐Ju Choi, Sangjin Kang, Jinwan Kim, Yong‐Soo Choi, Dong Hyun Kim, Ji Hae An, Inbo Han, Sunghou Lee, Min Ho Lee, Young Ho Kim, Ji Hyung Chung

CRH receptor antagonists Pulsatilla chinensis catagen transition hair follicles dermal papilla cells saponin derivatives stress-induced hair loss

TLDR Pulsatilla chinensis compounds may help prevent stress-related hair loss.

The study investigated the effects of CRH receptor antagonists from Pulsatilla chinensis on human hair follicles and dermal papilla cells, focusing on stress-induced hair loss. It was found that CRH induced early catagen transition and downregulated hair growth-related factors in an ex vivo hair organ culture model. CRH also activated stress-related signaling pathways in cultured dermal papilla cells. However, CRH receptor antagonists from P. chinensis reversed these effects, suggesting that saponin derivatives from this plant could be used as a treatment for stress-induced hair loss.

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