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GlossaryPlatelet-Derived Growth Factor Receptor (PDGF Receptor)

cell surface receptor that binds to growth factors for cell processes

Platelet-Derived Growth Factor Receptor (PDGFR) is a cell surface receptor that binds to platelet-derived growth factors (PDGFs). When PDGFs attach to PDGFR, it triggers a series of cellular processes, including cell growth, division, and survival. This receptor plays a crucial role in wound healing and the development of blood vessels, and its malfunction can be associated with various diseases, including cancers and fibrotic conditions.

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Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells

research Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells

17 citations, May 2015 in “Nanomedicine: Nanotechnology, Biology and Medicine”

Scientists created tiny particles loaded with a hair growth drug, minoxidil, that specifically target hair follicles and skin cells to potentially improve hair growth.

Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

134 citations, January 2010 in “Biomedical research”

Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.

research Growth Factors in Hair Organ Development and the Hair Growth Cycle

90 citations, October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

research The PDGF/PDGFR Pathway as a Drug Target

182 citations, November 2017 in “Molecular Aspects of Medicine”

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

research Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal

37 citations, April 2017 in “npj Regenerative Medicine”

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

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community Surprisingly thorough study on He-Shou-Wu/Fo Ti

in Research/Science 14 upvotes 1 year ago

He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.

community Seriously confused about minoxidil's method of action

in Minoxidil 6 upvotes 2 years ago

The conversation discusses confusion about how Minoxidil promotes hair growth compared to other substances like Menthol, which have similar actions. The user mentions personal positive results with peppermint oil extract and is currently trying L-citrulline for its vasodilation effects.

community 2 years later I managed to gain some ground (Hyperresponder)

in Progress Pictures 43 upvotes 1 year ago

The user regained most of their hair using Minoxidil, Finasteride, and Dermarolling. They found Dermarolling particularly effective, as it promotes growth factors and improves hair thickness.

community Comprehensive Microneedling Guide

in Microneedling 290 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.