Platelet-Rich Plasma Promotes Cell Viability of Human Hair Dermal Papilla Cells In Vitro

January 2017 in “ PubMed ”

Yuyan Wang, Chunmiao Zheng, Fei Zhu, Ming Jia

platelet-rich plasma human hair dermal papilla cells HHDPCs alkaline phosphatase ALP versican MTT assays qRT-PCR Western blot analysis hair follicle regeneration alopecia PRP

TLDR Platelet-rich plasma helps human hair cells grow and survive better.

The study demonstrated that platelet-rich plasma (PRP) significantly promoted the viability and proliferation of human hair dermal papilla cells (HHDPCs) in vitro, particularly at a 5% concentration. PRP also increased the expression of alkaline phosphatase (ALP) and versican at both mRNA and protein levels. The study involved 8 healthy volunteers and used MTT assays, qRT-PCR, and Western blot analysis. These findings suggested that PRP could be a potential therapeutic tool for promoting hair follicle regeneration and treating alopecia, although further research is needed to identify the specific growth factors responsible for these effects.

View this study on pubmed.ncbi.nlm.nih.gov →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

research Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution In Vivo

63 citations , October 2013 in “Dermatologic Surgery”

Platelet-Rich Plasma (PRP) increases the number of new hair follicles and speeds up hair formation.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth

166 citations , September 2011 in “Dermatologic Surgery”

Platelet-rich plasma with a new carrier significantly increases hair thickness without serious side effects.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

185 citations , August 2005 in “Autoimmunity Reviews”

Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.

Related Community Posts Join

6 / 103 results

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 43 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Difference between my hair wet and dry literally an hour apart

in Finasteride/Dutasteride 757 upvotes 3 months ago

The conversation is about hair loss treatments, focusing on minoxidil and finasteride, with suggestions for microneedling and dermarolling to improve hair thickness. The original poster has used minoxidil for four years and finasteride for over a year but is exploring additional options for better results.

community To my fellow under 20s that are balding

in Chat 127 upvotes 1 year ago

The conversation is about young men under 20 experiencing hair loss. They discuss their experiences and treatments used, including finasteride (fin) and minoxidil (min).

community Tom Cruise at the Mission Impossible premiere hair.(He's 61 y/o)

in Chat 392 upvotes 1 year ago

The conversation speculates on whether Tom Cruise uses hair loss treatments like Finasteride or Dutasteride, with some suggesting he naturally has good hair like Brad Pitt, while others joke about Scientology or genetics playing a role. Specific treatments mentioned include Finasteride, Dutasteride, and possibly high-quality hair products or procedures like PRP (Platelet-Rich Plasma).

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 85 upvotes 5 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

Related Research

1 / 1 results

research Platelet-Rich Plasma Promotes Cell Viability of Human Hair Dermal Papilla Cells In Vitro

January 2017 in “PubMed”

Platelet-rich plasma helps human hair cells grow and survive better.