Epiregulin Promotes Hair Growth Via EGFR-Mediated Epidermal and ErbB4-Mediated Dermal Stimulation

July 2020 in “ Cell Proliferation ”

Nahyun Choi, Won‐Serk Kim, Sang Ho Oh, Jong‐Hyuk Sung

epiregulin EGFR ErbB4 dermal papilla cells outer root sheath cells telogen-to-anagen transition reactive oxygen species

Studysummary In this study, EREG promoted hair growth by activating specific receptors in cell and animal models, indicating it may be a potential treatment for hair loss.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study found that epiregulin (EREG) promoted hair growth by activating EGFR in outer root sheath (ORS) cells and ErbB4 in dermal papilla cells (DPCs). EREG's activation of these receptors led to increased cell proliferation and migration, as well as regulation of reactive oxygen species (ROS) levels through NOX4 expression. EREG was primarily expressed during the anagen phase of hair cycling, and its knockdown inhibited hair growth, while subcutaneous injection promoted the telogen-to-anagen transition in mice. These findings suggested that EREG could be a potential therapeutic target for hair loss treatment.

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