CD34 Glycoprotein Identifies Putative Stem Cells Located in the Isthmic Region of Canine Hair Follicles

July 2006 in “ Veterinary dermatology ”

Luisa Pascucci, Francesca Mercati, Anna Gargiulo, V. Pedini, Silvia Sorbolini, Piero Ceccarelli

CD34 stem cells isthmic region hair follicles in situ hybridization immunohistochemistry basal keratinocytes outer root sheath

TLDR CD34 marks potential stem cells in dog hair follicles.

The study investigated the presence of CD34 as a marker for putative stem cells in the isthmic region of canine hair follicles. Using in situ hybridization and immunohistochemistry on formalin-fixed, paraffin-embedded canine skin samples, researchers found strong expression of CD34 mRNA and glycoprotein in the basal layer of the outer root sheath. This suggested that a subpopulation of basal keratinocytes in this region, characterized by CD34 expression, was potentially associated with the stem cell compartment in canine hair follicles.

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