TLDR CD34 marks potential stem cells in dog hair follicles.
The study investigated the presence of CD34 as a marker for putative stem cells in the isthmic region of canine hair follicles. Using in situ hybridization and immunohistochemistry on formalin-fixed, paraffin-embedded canine skin samples, researchers found strong expression of CD34 mRNA and glycoprotein in the basal layer of the outer root sheath. This suggested that a subpopulation of basal keratinocytes in this region, characterized by CD34 expression, was potentially associated with the stem cell compartment in canine hair follicles.
550 citations
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December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
142 citations
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June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Hair follicle stem cells can generate all hair cell types, skin, and sebaceous glands.
72 citations
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June 2001 in “Journal of Investigative Dermatology” S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.
949 citations
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January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations
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August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
45 citations
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April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.
122 citations
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July 1994 in “Journal of Investigative Dermatology”
