TLDR CD34 marks potential stem cells in dog hair follicles.
The study investigated the presence of CD34 as a marker for putative stem cells in the isthmic region of canine hair follicles. Using in situ hybridization and immunohistochemistry on formalin-fixed, paraffin-embedded canine skin samples, researchers found strong expression of CD34 mRNA and glycoprotein in the basal layer of the outer root sheath. This suggested that a subpopulation of basal keratinocytes in this region, characterized by CD34 expression, was potentially associated with the stem cell compartment in canine hair follicles.
550 citations,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
142 citations,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Hair follicle stem cells can generate all hair cell types, skin, and sebaceous glands.
72 citations,
June 2001 in “Journal of Investigative Dermatology” S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.
949 citations,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
45 citations,
April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.
