CD34 Glycoprotein Identifies Putative Stem Cells Located in the Isthmic Region of Canine Hair Follicles

    August 2006 in “ Veterinary dermatology
    Luisa Pascucci, Francesca Mercati, Anna Gargiulo, V. Pedini, Silvia Sorbolini, Piero Ceccarelli
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    TLDR CD34 marks potential stem cells in dog hair follicles.
    The study investigated the presence of CD34 as a marker for putative stem cells in the isthmic region of canine hair follicles. Using in situ hybridization and immunohistochemistry on formalin-fixed, paraffin-embedded canine skin samples, researchers found strong expression of CD34 mRNA and glycoprotein in the basal layer of the outer root sheath. This suggested that a subpopulation of basal keratinocytes in this region, characterized by CD34 expression, was potentially associated with the stem cell compartment in canine hair follicles.
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