Extracellular Vesicles From Adipose-Derived Stem Cells Ameliorate Ultraviolet B-Induced Skin Photoaging by Attenuating Reactive Oxygen Species Production and Inflammation

    July 2020 in “ Stem Cell Research & Therapy ”
    Peng Xu, Xin Yu, Zheng Zhang, Xiangyu Zou, Ke Xue, Huizhong Zhang, Wenjie Zhang, Kai Liu
    TLDR Stem cell vesicles can reduce skin aging from UVB by lowering inflammation and oxidative stress.
    The study demonstrated that extracellular vesicles derived from adipose-derived stem cells (ADSC-EVs) effectively ameliorated ultraviolet B (UVB)-induced skin photoaging in mice by reducing reactive oxygen species (ROS) production and inflammation. Researchers observed improvements in skin texture, increased epidermal cell proliferation, and decreased macrophage infiltration. In vitro experiments showed enhanced fibroblast activity and protection against UVB-induced senescence. The study highlighted the potential of ADSC-EVs as a stable and easily obtainable therapeutic agent for skin photoaging, offering advantages over traditional stem cell therapies due to their lower risk of immune rejection and tumorigenicity.
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